Studying a mycovirus from Dothistroma septosporum
Carried out by: Imperial College London
Further to recent research supported by the SFT, the research team at Imperial College have identified a D. septosporum isolate harbouring a double-stranded (ds) RNA mycovirus belonging to the family Chrysoviridae. The aims of this research are (1) to provide insight into the effects of the virus on host growth and virulence, and therefore its potential as a biological control agent against Dothistroma needle blight (DNB), and (2) to understand the molecular mechanisms underpinning these effects by investigating the transcriptional and small RNA profile of the D. septosporum isolate in the presence of the virus. Ideally by the completion of the project it should be possible to link fungal growth and virulence phenotypes with specific groups of genes up- or down-regulated in virus-free and virus-infected isolates and propose a RNA silencing based mechanism to explain this differential expression. The research is expected to take up to 2 years.
SFT Funds Awarded: £32,000